|
|
|
|
|
Click Here to return To Results
|
|
|
|
Recently published large clinical trails of heparin and aspirin in acute stroke-the International Stroke Trial, Chinese Acute Stroke Trial, and Trial of ORG 10172 in Acute Stroke Treatment-fail to show a net benefit from heparin. None of these trials used IV, dose-adjusted, unfractionated heparin as generally employed in the United States. However, the control groups in these trials provide data on acute stroke recurrence in large numbers of patients, and these stroke recurrence rates ca n be used to establish an upper limit for the potential efficacy of antithrombotic therapy. The rates of recurrent ischemic stroke in the control groups of these trials were low, ranging from 0.6% to 2.2% per week. The low rates of recurrent stroke obse rved in these groups, coupled with the morbidity and mortality associated with IV heparin in this patient population, argue against routine use of IV heparin in the acute stroke period. |
|
(click to filter results - removes previous filter)
anticoagulant,complications of
anticoagulant,treatment
anticoagulant,treatment in CVD
cerebrovascular accident
cerebrovascular accident,acute management of
heparin
review article
risk-benefit assessment
|
Click Here to return To Results
|
|